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CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 (IC50 = <0.5 µM in a cell-free assay) and inhibits LPS-induced IL-6 secretion in THP-1 cells (IC50 = <0.5 µM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.06 mL | 125.3 mL | 250.6 mL |
| 0.5 mM | 5.01 mL | 25.06 mL | 50.12 mL |
| 1 mM | 2.51 mL | 12.53 mL | 25.06 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
*The above data is based on the productmolecular weight 399.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15828 |
|---|---|
| CAS No. | 1380087-86-4 |
| Formula | C20H15Cl2N3O2 |
| M. Wt | 399.05 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | CPI 268456, CPI268456 |
| SMILES | C(N)(=O)C[[email protected]@H]1N=C(C2=CC=C(Cl)C=C2)C2=CC(Cl)=CC=C2C2C(C)=NOC=21 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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