Crenolanib (CP-868596)

Catalog No.: A11052

PDGFR/FLT3 Inhibitor

Crenolanib (CP-868596)

Crenolanib (CP-868596) Chemical Structure

CAS NO. 670220-88-9

Crenolanib (CP-868596) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
50 mg
$400.00
100 mg
$640.00
10mM * 1mL in DMSO
$120.00
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  • N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755

Biological Activity

Crenolanib (CP-868596) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations.
Targets
PDGFRα (CHO cells) PDGFRβ (CHO cells) FLT3
2.1 nM(Kd)3.2 nM(Kd)0.74 nM (Kd)
In vitro (25°C) DMSO Warmed: 84 mg/mL (189.38 mM)
Water Insoluble
Ethanol 7 mg/mL (15.78 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.74 mL 225.48 mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11052
Actions Inhibitor
CAS No. 670220-88-9
Formula C26H29N5O2
M. Wt 443.5
Solubility DMSO
Purity >98%
Synonyms CP868596, CP 868596
SMILES CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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