CS-0777-P is a potent and selective agonist of the sphingosine 1-phosphate receptor 1 (S1P1). It displays approximately 320-fold higher activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. Biological studies indicate its capability to significantly reduce peripheral blood lymphocyte counts and exert immunosuppressive effects in experimental autoimmune encephalomyelitis models in rats. Pharmacokinetic analysis reveals swift lymphocyte count reductions after oral administration, highlighting CS-0777-P's potential as a therapeutic candidate for multiple sclerosis, currently under clinical investigation.
CS-0777-P is a potent and selective agonist of the sphingosine 1-phosphate receptor 1 (S1P1). It displays approximately 320-fold higher activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. Biological studies indicate its capability to significantly reduce peripheral blood lymphocyte counts and exert immunosuppressive effects in experimental autoimmune encephalomyelitis models in rats. Pharmacokinetic analysis reveals swift lymphocyte count reductions after oral administration, highlighting CS-0777-P's potential as a therapeutic candidate for multiple sclerosis, currently under clinical investigation.
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