Cycloleucine is a selective NMDA receptor antagonist that targets the glycine site, exhibiting a Ki value of 600 μM. This compound inhibits S-adenosyl-methionine-mediated methylation and acts as a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine demonstrates anxiolytic and cytostatic properties, making it a valuable tool for research in neurobiology and cancer studies. Its unique mechanism of action provides insights into the underlying pathways of excitotoxicity and cellular regulation.
Cycloleucine is a selective NMDA receptor antagonist that targets the glycine site, exhibiting a Ki value of 600 μM. This compound inhibits S-adenosyl-methionine-mediated methylation and acts as a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine demonstrates anxiolytic and cytostatic properties, making it a valuable tool for research in neurobiology and cancer studies. Its unique mechanism of action provides insights into the underlying pathways of excitotoxicity and cellular regulation.
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