D 15413 is an orally active nonsteroidal estrogen antagonist that effectively inhibits the growth of estrogen receptor-positive MCF-7 cells, achieving a 70% inhibition rate at a concentration of 10^-7 M. This compound demonstrates significant antitumor activity in models of breast cancer induced by DMBA and MNU, making it a valuable tool for research in breast cancer therapeutics and estrogen signaling pathways.
D 15413 is an orally active nonsteroidal estrogen antagonist that effectively inhibits the growth of estrogen receptor-positive MCF-7 cells, achieving a 70% inhibition rate at a concentration of 10^-7 M. This compound demonstrates significant antitumor activity in models of breast cancer induced by DMBA and MNU, making it a valuable tool for research in breast cancer therapeutics and estrogen signaling pathways.
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