Dabrafenib Mesylate

Catalog No.: A15059

Raf inhibitor

Dabrafenib Mesylate Chemical Structure

CAS NO. 1195768-06-9

Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$60.00
50 mg
$90.00
100 mg
$126.00

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Biological Activity

Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.24 mL 81.21 mL 162.42 mL
0.5 mM 3.25 mL 16.24 mL 32.48 mL
1 mM 1.62 mL 8.12 mL 16.24 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15059
Actions Inhibitor
M. Wt 615.67
Formula C24H24F3N5O5S3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1195768-06-9
Synonyms GSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B
SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O

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