Dalmelitinib is a selective c-Met kinase inhibitor with an IC50 of 2.9 nM, targeting the ATP-binding region of the c-Met receptor. This compound effectively induces phosphorylation of MET while partially or completely inhibiting the phosphorylation of downstream signaling proteins AKT and ERK. Dalmelitinib demonstrates potent anti-proliferative effects on cancer cells with c-Met oncogene amplification, making it a valuable reagent for research applications in cancers such as human non-small cell lung cancer (NSCLC).
Dalmelitinib is a selective c-Met kinase inhibitor with an IC50 of 2.9 nM, targeting the ATP-binding region of the c-Met receptor. This compound effectively induces phosphorylation of MET while partially or completely inhibiting the phosphorylation of downstream signaling proteins AKT and ERK. Dalmelitinib demonstrates potent anti-proliferative effects on cancer cells with c-Met oncogene amplification, making it a valuable reagent for research applications in cancers such as human non-small cell lung cancer (NSCLC).
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