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Biological Activity
Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.33 mL | 116.67 mL | 233.33 mL |
| 0.5 mM | 4.67 mL | 23.33 mL | 46.67 mL |
| 1 mM | 2.33 mL | 11.67 mL | 23.33 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11789 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 139340-56-0 |
| Formula | C19H28N2O5S2 |
| M. Wt | 428.57 |
| Purity | >98% |
| Synonyms | CI-1004 mesylate |
| SMILES | O=C1N=C(N)S/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2.CS(=O)(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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