Darbufelone mesylate

Catalog No.: A11789

PGF2α/LTB4 production inhibitor

Darbufelone mesylate

Darbufelone mesylate Chemical Structure

CAS NO. 139340-56-0

Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).

Availability: In stock

Package Price Qty
1 mg
$216.00
5 mg
$648.00
10 mg
$1,104.00
50 mg
$3,312.00
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Biological Activity

Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.33 mL 116.67 mL 233.33 mL
0.5 mM 4.67 mL 23.33 mL 46.67 mL
1 mM 2.33 mL 11.67 mL 23.33 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11789
Actions Inhibitor
CAS No. 139340-56-0
Formula C19H28N2O5S2
M. Wt 428.57
Solubility DMSO
Purity >98%
Synonyms CI-1004 mesylate
SMILES O=C1N=C(N)S/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2.CS(=O)(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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