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Biological Activity
DBPR112 is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.74 mL | 93.7 mL | 187.4 mL |
| 0.5 mM | 3.75 mL | 18.74 mL | 37.48 mL |
| 1 mM | 1.87 mL | 9.37 mL | 18.74 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.75 mL |
*The above data is based on the productmolecular weight 533.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18857 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1226549-49-0 |
| Formula | C32H31N5O3 |
| M. Wt | 533.62 |
| Purity | >98% |
| Synonyms | DBPR 112, DBPR-112 |
| SMILES | O=C(NC1=CC=CC(C2=C(C3=CC=CC=C3)OC4=NC=NC(N[[email protected]@H](C5=CC=CC=C5)CO)=C42)=C1)/C=C/CN(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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