DBPR112

Catalog No.: A18857

EGFR inhibitor

DBPR112

DBPR112 Chemical Structure

CAS NO. 1226549-49-0

DBPR112 is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

DBPR112 is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.74 mL 93.7 mL 187.4 mL
0.5 mM 3.75 mL 18.74 mL 37.48 mL
1 mM 1.87 mL 9.37 mL 18.74 mL
5 mM 0.37 mL 1.87 mL 3.75 mL

*The above data is based on the productmolecular weight 533.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18857
Actions Inhibitor
CAS No. 1226549-49-0
Formula C32H31N5O3
M. Wt 533.62
Solubility DMSO
Purity >98%
Synonyms DBPR 112, DBPR-112
SMILES O=C(NC1=CC=CC(C2=C(C3=CC=CC=C3)OC4=NC=NC(N[[email protected]@H](C5=CC=CC=C5)CO)=C42)=C1)/C=C/CN(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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