DDD85646 is a potent inhibitor of N-myristoyltransferase (NMT), specifically targeting the enzyme from Trypanosoma brucei with an IC50 of 2 nM and human NMT with an IC50 of 4 nM. This compound demonstrates significant potential for therapeutic applications in treating human African trypanosomiasis by disrupting lipid modifications essential for parasite survival. Its oral bioavailability further enhances its applicability in drug development for infectious diseases caused by trypanosomes.
DDD85646 is a potent inhibitor of N-myristoyltransferase (NMT), specifically targeting the enzyme from Trypanosoma brucei with an IC50 of 2 nM and human NMT with an IC50 of 4 nM. This compound demonstrates significant potential for therapeutic applications in treating human African trypanosomiasis by disrupting lipid modifications essential for parasite survival. Its oral bioavailability further enhances its applicability in drug development for infectious diseases caused by trypanosomes.
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