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Deforolimus (Ridaforolimus) is an investigational targeted and small-molecule inhibitor of the protein mTOR. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.
Targets
| mTOR (HT-1080 cells) | ||||
| 0.2 nM |
| In vitro (25°C) | DMSO | 198 mg/mL (199.95 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 20 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.1 mL | 50.49 mL | 100.99 mL |
| 0.5 mM | 2.02 mL | 10.1 mL | 20.2 mL |
| 1 mM | 1.01 mL | 5.05 mL | 10.1 mL |
| 5 mM | 0.2 mL | 1.01 mL | 2.02 mL |
*The above data is based on the productmolecular weight 990.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A10295 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 990.2 |
| Formula | C53H84NO14P |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 572924-54-0 |
| Synonyms | AP23573, MK-8669, MK8669 |
| SMILES | C[[email protected]@H]1CC[[email protected]]2C[[email protected]@H](/C(=C/C=C/C=C/[[email protected]](C[[email protected]](C(=O)[[email protected]@H]([[email protected]@H](/C(=C/[[email protected]](C(=O)C[[email protected]](OC(=O)[[email protected]@H]3CCCCN3C(=O)C(=O)[[email protected]@]1(O2)O)[[email protected]](C)C[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)OP(=O)(C)C)C)/C)O)OC)C)C)/C)OC |
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