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Deoxy-thalidomide-C4-NH2

Catalog No.: A80209
E3 Ligase Ligand-Linker Conjugate
Deoxy-thalidomide-C4-NH2 is a ligand-linker conjugate targeting the E3 ligase Cereblon (CRBN). This compound facilitates the development of Proteolysis Targeting Chimeras (PROTACs), specifically for synthesizing BRD4 degraders. Its unique structure supports targeted protein degradation, making it a valuable tool for research in cellular protein regulation and therapeutics.
Deoxy-thalidomide-C4-NH2 2940934-97-2 E3 Ligase Ligand-Linker Conjugate
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDeoxy-thalidomide-C4-NH2 is a ligand-linker conjugate targeting the E3 ligase Cereblon (CRBN). This compound facilitates the development of Proteolysis Targeting Chimeras (PROTACs), specifically for synthesizing BRD4 degraders. Its unique structure supports targeted protein degradation, making it a valuable tool for research in cellular protein regulation and therapeutics.
Product Information
Catalog NumA80209
FormulaC17H21N3O3
Molecular Weight315.37
CAS Number2940934-97-2
SMILESO=C1NC(C(CC1)N2C(C3=CC=C(CCCCN)C=C3C2)=O)=O
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PROTAC > E3 Ligase Ligand-Linker Conjugate