Desamino lenalidomide-acetylene-piperidine

Catalog No.: A80303
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-acetylene-piperidine is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand with a linker structure. This compound is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), thereby enabling targeted protein degradation in cellular systems. It is valuable for investigative studies aimed at elucidating cellular mechanisms and developing novel therapeutic strategies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDesamino lenalidomide-acetylene-piperidine is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand with a linker structure. This compound is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), thereby enabling targeted protein degradation in cellular systems. It is valuable for investigative studies aimed at elucidating cellular mechanisms and developing novel therapeutic strategies.
Product Information
Catalog NumA80303
FormulaC20H21N3O3
Molecular Weight351.41
CAS Number2138440-50-1
SMILESO=C1NC(=O)C(N2C(=O)C=3C=CC=C(C#CC4CCNCC4)C3C2)CC1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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