Desamino lenalidomide-C-piperazine

Catalog No.: A80365
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-C-piperazine is an E3 ligase ligand-linker conjugate designed for the targeted degradation of specific proteins. The compound features a cereblon (CRBN)-based ligand, enabling the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This reagent is valuable for research applications involving protein modulation and the study of protein homeostasis pathways. It may facilitate the development of targeted therapies in various disease models, including cancer.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDesamino lenalidomide-C-piperazine is an E3 ligase ligand-linker conjugate designed for the targeted degradation of specific proteins. The compound features a cereblon (CRBN)-based ligand, enabling the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This reagent is valuable for research applications involving protein modulation and the study of protein homeostasis pathways. It may facilitate the development of targeted therapies in various disease models, including cancer.
Product Information
Catalog NumA80365
FormulaC18H22N4O3
Molecular Weight342.40
CAS Number2883559-70-2
SMILESO=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)CN4CCNCC4)CC1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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