Fig. 1 · Structure
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Desamino lenalidomide-NO2
Ligand for E3 Ligase
Desamino lenalidomide-NO2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation pathways. This compound can be conjugated to target protein ligands through a linker to design and develop PROTAC (proteolysis-targeting chimeras) molecules, enabling precise modulation of protein levels in research applications. Its utility in studying protein degradation mechanisms makes it a valuable tool for drug discovery and cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1198787-23-3 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| SMILES | O=C1C2=CC=C([N+]([O-])=O)C=C2CN1C3C(NC(CC3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.