Desamino lenalidomide-Pip-CO-piperazine hydrochloride

Catalog No.: A80391
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-Pip-CO-piperazine hydrochloride is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound incorporates a cereblon (CRBN)-based ligand and a piperazine linker, facilitating the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a valuable tool for researchers investigating innovative therapeutic strategies through modulation of protein levels via the ubiquitin-proteasome system.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionDesamino lenalidomide-Pip-CO-piperazine hydrochloride is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound incorporates a cereblon (CRBN)-based ligand and a piperazine linker, facilitating the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a valuable tool for researchers investigating innovative therapeutic strategies through modulation of protein levels via the ubiquitin-proteasome system.
Product Information
Catalog NumA80391
FormulaC23H30ClN5O4
Molecular Weight475.97
CAS Number2933214-25-4
SMILESO=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC4)C(C5CCNCC5)=O)C=C3C2)=O)=O.Cl
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