Desamino lenalidomide-piperidine-O-7-azaspiro3.5nonane

Catalog No.: A80323
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-piperidine-O-7-azaspiro[3.5]nonane serves as an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) by linking a target protein with an E3 ubiquitin ligase. Its application in targeted protein degradation research underscores its potential to advance therapeutic strategies within the fields of oncology and cellular signaling.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDesamino lenalidomide-piperidine-O-7-azaspiro[3.5]nonane serves as an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) by linking a target protein with an E3 ubiquitin ligase. Its application in targeted protein degradation research underscores its potential to advance therapeutic strategies within the fields of oncology and cellular signaling.
Product Information
Catalog NumA80323
FormulaC26H34N4O4
Molecular Weight466.58
CAS Number3032321-43-7
SMILESO=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)N4CCC(OC5CC6(CCNCC6)C5)CC4)CC1
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