(±)-Desisopropylpropranolol serves as a metabolite of Propranolol, a nonselective β-adrenergic receptor antagonist that demonstrates high binding affinity for β1AR and β2AR with inhibition constants (Kis) of 1.8 nM and 0.8 nM, respectively. This compound effectively inhibits [3H]-DHA binding to rat brain membrane preparations with an IC50 of 12 nM. Research applications include investigations into cardiovascular conditions such as hypertension, myocardial infarction, cardiac arrhythmias, and angina pectoris, as well as studying mechanisms relevant to pheochromocytoma and hypertrophic cardiomyopathy.
(±)-Desisopropylpropranolol serves as a metabolite of Propranolol, a nonselective β-adrenergic receptor antagonist that demonstrates high binding affinity for β1AR and β2AR with inhibition constants (Kis) of 1.8 nM and 0.8 nM, respectively. This compound effectively inhibits [3H]-DHA binding to rat brain membrane preparations with an IC50 of 12 nM. Research applications include investigations into cardiovascular conditions such as hypertension, myocardial infarction, cardiac arrhythmias, and angina pectoris, as well as studying mechanisms relevant to pheochromocytoma and hypertrophic cardiomyopathy.
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