DHODH-IN-4 is a dihydroorotate dehydrogenase (DHODH) inhibitor targeting both human and Plasmodium falciparum DHODH. With IC50 values of 4 μM for PfDHODH and 0.18 μM for HsDHODH, this compound demonstrates significant potential as an antimalarial agent. It is suitable for research applications focused on understanding malaria pathology and developing effective treatments against Plasmodium infections.
DHODH-IN-4 is a dihydroorotate dehydrogenase (DHODH) inhibitor targeting both human and Plasmodium falciparum DHODH. With IC50 values of 4 μM for PfDHODH and 0.18 μM for HsDHODH, this compound demonstrates significant potential as an antimalarial agent. It is suitable for research applications focused on understanding malaria pathology and developing effective treatments against Plasmodium infections.
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