Dihydrochalcone is an Aβ aggregation inhibitor that destabilizes Aβ17-42 protofibrils by disrupting the β-sheet structure in the β1 region. This compound effectively targets both U-shaped Aβ40/Aβ42 and S-shaped Aβ42 protofibrils by binding to their respective protofibril cavities. Dihydrochalcone, primarily derived from the daemonorops draco tree, is of significant interest in Alzheimer's disease research and offers potential for studying therapeutic strategies aimed at preventing amyloid-beta aggregation.
Dihydrochalcone is an Aβ aggregation inhibitor that destabilizes Aβ17-42 protofibrils by disrupting the β-sheet structure in the β1 region. This compound effectively targets both U-shaped Aβ40/Aβ42 and S-shaped Aβ42 protofibrils by binding to their respective protofibril cavities. Dihydrochalcone, primarily derived from the daemonorops draco tree, is of significant interest in Alzheimer's disease research and offers potential for studying therapeutic strategies aimed at preventing amyloid-beta aggregation.
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