Dimethothiazine mesylate is an orally active tricyclic antihistamine and anti-5-HT agent that exhibits significant activity against decerebrate rigidity, demonstrating minimal sedative and soporific effects. This compound effectively reduces or eliminates the influence of both static and dynamic fusimotor activity on muscle spindles in decerebrate models. Dimethothiazine mesylate is relevant for research applications related to hemicrania and spasticity.
Dimethothiazine mesylate is an orally active tricyclic antihistamine and anti-5-HT agent that exhibits significant activity against decerebrate rigidity, demonstrating minimal sedative and soporific effects. This compound effectively reduces or eliminates the influence of both static and dynamic fusimotor activity on muscle spindles in decerebrate models. Dimethothiazine mesylate is relevant for research applications related to hemicrania and spasticity.
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