Dimethyl 3-hydroxyphthalate-amido-C4-N3

Catalog No.: A80376
E3 Ligase Ligand-Linker Conjugate
Dimethyl 3-hydroxyphthalate-amido-C4-N3 is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand. This compound serves as a crucial component in the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It facilitates the recruitment of E3 ligases, which are essential for the ubiquitination process, making it valuable for research in targeted therapy and protein regulation studies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDimethyl 3-hydroxyphthalate-amido-C4-N3 is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand. This compound serves as a crucial component in the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It facilitates the recruitment of E3 ligases, which are essential for the ubiquitination process, making it valuable for research in targeted therapy and protein regulation studies.
Product Information
Catalog NumA80376
FormulaC16H20N4O6
Molecular Weight364.36
CAS Number2098492-26-1
SMILES[N-]=[N+]=NCCCCNC(=O)COC1=CC=CC(C(=O)OC)=C1C(=O)OC
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