Dizocilpine is a potent, non-competitive antagonist of the NMDA receptor, characterized by a Kd of 37.2 nM in rat brain membranes. By binding to a specific site within the NMDA-associated ion channel, it effectively inhibits calcium ion (Ca2+) influx. This compound is widely used in research focused on epilepsy, neurotoxicity, and neurodegenerative diseases, making it a valuable tool for studying excitotoxicity and synaptic function.
Dizocilpine is a potent, non-competitive antagonist of the NMDA receptor, characterized by a Kd of 37.2 nM in rat brain membranes. By binding to a specific site within the NMDA-associated ion channel, it effectively inhibits calcium ion (Ca2+) influx. This compound is widely used in research focused on epilepsy, neurotoxicity, and neurodegenerative diseases, making it a valuable tool for studying excitotoxicity and synaptic function.
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