Doxapram hydrochloride is a ventilatory stimulant that primarily functions as an inhibitor of TASK (Tandem Pore) potassium channels. It specifically inhibits TASK-1 and TASK-3 channels, exhibiting EC50 values of 410 nM and 37 nM, respectively, and also affects TASK-1/TASK-3 heterodimer channels with an EC50 of 9 μM. This compound is valuable for research applications focused on respiratory stimulation, particularly in the study of apnea in preterm infants.
Doxapram hydrochloride is a ventilatory stimulant that primarily functions as an inhibitor of TASK (Tandem Pore) potassium channels. It specifically inhibits TASK-1 and TASK-3 channels, exhibiting EC50 values of 410 nM and 37 nM, respectively, and also affects TASK-1/TASK-3 heterodimer channels with an EC50 of 9 μM. This compound is valuable for research applications focused on respiratory stimulation, particularly in the study of apnea in preterm infants.
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