DPP-4/GPR119 Modulator 1 is a dual-functional compound that serves as an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and a GPR119 agonist. This compound exhibits significant blood glucose-lowering effects and demonstrates moderate hERG channel inhibition with an IC50 of 4.9 μM. DPP-4/GPR119 Modulator 1 is particularly valuable in diabetes research and functions as a click chemistry reagent, possessing an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
DPP-4/GPR119 Modulator 1 is a dual-functional compound that serves as an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and a GPR119 agonist. This compound exhibits significant blood glucose-lowering effects and demonstrates moderate hERG channel inhibition with an IC50 of 4.9 μM. DPP-4/GPR119 Modulator 1 is particularly valuable in diabetes research and functions as a click chemistry reagent, possessing an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
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