DPTIP-prodrug 18 is an orally active prodrug that demonstrates high brain penetrability and functions as a potent nSMase2 inhibitor. It effectively inhibits IL-1β-induced release of extracellular vesicles by targeting and inhibiting the activity of neutral sphingomyelinase-2. This compound is suitable for research in brain injury studies, providing insights into the molecular mechanisms of neuroinflammation and extracellular signaling.
DPTIP-prodrug 18 is an orally active prodrug that demonstrates high brain penetrability and functions as a potent nSMase2 inhibitor. It effectively inhibits IL-1β-induced release of extracellular vesicles by targeting and inhibiting the activity of neutral sphingomyelinase-2. This compound is suitable for research in brain injury studies, providing insights into the molecular mechanisms of neuroinflammation and extracellular signaling.
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