DS45500853 is an agonist of estrogen-related receptor α (ERRα), functioning by inhibiting the interaction between the receptor-interacting protein 140 (RIP140) corepressor peptide and the GST-ERRα ligand-binding domain, with an IC50 value of 0.80 μM. This compound is relevant for research into metabolic disorders, particularly type 2 diabetes mellitus (T2DM), providing insights into ERRα signaling pathways and their implications in metabolic regulation.
DS45500853 is an agonist of estrogen-related receptor α (ERRα), functioning by inhibiting the interaction between the receptor-interacting protein 140 (RIP140) corepressor peptide and the GST-ERRα ligand-binding domain, with an IC50 value of 0.80 μM. This compound is relevant for research into metabolic disorders, particularly type 2 diabetes mellitus (T2DM), providing insights into ERRα signaling pathways and their implications in metabolic regulation.
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