Duostatin 5 is an ADC cytotoxin that serves as a synthetic building block for antibody-drug conjugates (ADCs). It is derived from MMAF and allows for efficient conjugation to antibodies targeting 5T4 through a disubstituted C-Lock linker, enabling stable and straightforward synthesis. Duostatin 5 features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is valuable for researchers developing targeted therapies in cancer treatment.
Duostatin 5 is an ADC cytotoxin that serves as a synthetic building block for antibody-drug conjugates (ADCs). It is derived from MMAF and allows for efficient conjugation to antibodies targeting 5T4 through a disubstituted C-Lock linker, enabling stable and straightforward synthesis. Duostatin 5 features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is valuable for researchers developing targeted therapies in cancer treatment.
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