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Publications citing Adooq Products
Dynasore Citations (3)
- Tsukamoto H,et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 29760187
- Shigetoshi Yokoyama,et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 30526845
- Naoko Fujii,et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 27733684
Chemical Information
| Catalog Num | A12726 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 322.32 |
| Formula | C18H14N2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 304448-55-3 |
| Synonyms | N/A |
| SMILES code | C1=CC=C2C=C(C(=CC2=C1)C(=O)NN/C=C/3\C=CC(=O)C(=C3)O)O |
| Chemical Name | 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide |
Description |
Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C)* | In vitro | DMSO | 64 mg/mL (198.56 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.03 mL | 155.13 mL | 310.25mL |
| 0.5 mM | 6.21 mL | 31.03 mL | 62.05 mL |
| 1 mM | 3.1 mL | 15.51 mL | 31.03 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.21 mL |
*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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