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Dynasore

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Dynamin inhibitor

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Catalog No. A12726

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Dynasore 10mg A12726-10

Regular Price: €38.00

Special Price: €34.20

Dynasore 25mg A12726-25

Regular Price: €76.00

Special Price: €68.40

Dynasore 50mg A12726-50

Regular Price: €133.00

Special Price: €119.70

Dynasore 100mg A12726-100

Regular Price: €237.50

Special Price: €213.75

Dynasore 10mM * 1mL in DMSO A12726-10mM-D

Regular Price: €68.40

Special Price: €61.56

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity

Dynasore

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Publications citing Adooq Products
Dynasore Citations (3)
  • Tsukamoto H,et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 29760187
  • Shigetoshi Yokoyama,et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 30526845
  • Naoko Fujii,et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 27733684

Chemical Information

Catalog Num A12726
Actions Inhibitor
M. Wt 322.32
Formula C18H14N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 304448-55-3
Synonyms N/A
SMILES code C1=CC=C2C=C(C(=CC2=C1)C(=O)NN/C=C/3\C=CC(=O)C(=C3)O)O
Chemical Name 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

Biological Activity

Description
Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity
Targets
Dynamin1/2 (Cell-free assay)
~15 μM

Solubility

Solubility (25°C)* In vitro DMSO 64 mg/mL (198.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.03 mL 155.13 mL 310.25mL
0.5 mM 6.21 mL 31.03 mL 62.05 mL
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL

*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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