Dyrk1A-IN-16 is a selective DYRK1A inhibitor that operates as an ATP-competitive antagonist with an IC50 of 53 nM. This compound exhibits strong selectivity for DYRK kinases and demonstrates nanomolar potency in biological assays. In vitro studies reveal that Dyrk1A-IN-16 effectively impairs neurosphere self-renewal, cell invasion, and EGFR stability. In vivo, it has been shown to inhibit tumor growth and extend survival, indicating its potential utility in glioblastoma research.
Dyrk1A-IN-16 is a selective DYRK1A inhibitor that operates as an ATP-competitive antagonist with an IC50 of 53 nM. This compound exhibits strong selectivity for DYRK kinases and demonstrates nanomolar potency in biological assays. In vitro studies reveal that Dyrk1A-IN-16 effectively impairs neurosphere self-renewal, cell invasion, and EGFR stability. In vivo, it has been shown to inhibit tumor growth and extend survival, indicating its potential utility in glioblastoma research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
