(E)-XS-060 is a selective RXRα antagonist that disrupts the interaction between pRXRα and PLK1. This compound induces RXRα-dependent mitotic arrest, thereby inhibiting cell proliferation. Its notable antitumor activity has been demonstrated in various cancer models, including breast cancer, lung adenocarcinoma, and liver cancer, making it a valuable tool for cancer research and therapeutic development.
(E)-XS-060 is a selective RXRα antagonist that disrupts the interaction between pRXRα and PLK1. This compound induces RXRα-dependent mitotic arrest, thereby inhibiting cell proliferation. Its notable antitumor activity has been demonstrated in various cancer models, including breast cancer, lung adenocarcinoma, and liver cancer, making it a valuable tool for cancer research and therapeutic development.
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