Fig. 1 · Structure
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(E/Z)-Chk2-IN-1
Chk2 Inhibitor
(E/Z)-Chk2-IN-1 is a potent and selective inhibitor of the cell cycle kinase Chk2, with an IC50 of 8 nM. This compound demonstrates minimal inhibitory activity against other kinases, including CK1δ, MEK1, and PKCα/βⅡ, with IC50 values greater than 89 nM. (E/Z)-Chk2-IN-1 is suitable for research applications in cancer biology, particularly in elucidating the role of Chk2 in cell cycle regulation and tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 693222-51-4 |
| Applications | Chk2 Inhibitor |
| Formula | C15H13N5O2 |
| Molecular Weight | 295.30 |
| Synonyms | (E/Z)-Hymenialdisine analogue-1 |
| SMILES | O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.