(E/Z)-N-Desethylsunitinib hydrochloride is a potent inhibitor of phosphodiesterase (PDE), functioning as a competitive inhibitor of ATP. This compound exhibits significant anti-tumor activity by targeting and inhibiting VEGF-R2 and PDGF-Rβ tyrosine kinases. Its role as the principal active metabolite of sunitinib makes it valuable for research applications focused on tumor angiogenesis and proliferation.
(E/Z)-N-Desethylsunitinib hydrochloride is a potent inhibitor of phosphodiesterase (PDE), functioning as a competitive inhibitor of ATP. This compound exhibits significant anti-tumor activity by targeting and inhibiting VEGF-R2 and PDGF-Rβ tyrosine kinases. Its role as the principal active metabolite of sunitinib makes it valuable for research applications focused on tumor angiogenesis and proliferation.
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