E0924G is an orally active PPARδ activator with an EC50 of 2.82 μM. This compound effectively induces the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM, demonstrating significant inhibition of RANKL-induced osteoclast differentiation and F-actin ring formation in RAW264.7 macrophages. E0924G has potential applications in research focused on bone density regulation and the treatment of bone loss in models of ovariectomized and age-related osteoporosis.
E0924G is an orally active PPARδ activator with an EC50 of 2.82 μM. This compound effectively induces the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 μM, demonstrating significant inhibition of RANKL-induced osteoclast differentiation and F-actin ring formation in RAW264.7 macrophages. E0924G has potential applications in research focused on bone density regulation and the treatment of bone loss in models of ovariectomized and age-related osteoporosis.
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