E3 Ligase Ligand-linker Conjugate 135

Catalog No.: A80326
E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-linker Conjugate 135 is a critical intermediate composed of an E3 ligase ligand and a linker, designed for use in the synthesis of complete PROTAC molecules. This compound facilitates the targeted degradation of proteins, specifically functioning in the context of the pan-KRAS degrader 5. It serves as a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand-linker Conjugate 135 is a critical intermediate composed of an E3 ligase ligand and a linker, designed for use in the synthesis of complete PROTAC molecules. This compound facilitates the targeted degradation of proteins, specifically functioning in the context of the pan-KRAS degrader 5. It serves as a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications.
Product Information
Catalog NumA80326
FormulaC30H44N6O3
Molecular Weight536.71
CAS Number3052748-49-6
SMILESO=C(NC1=O)CCC1N(C(N2C)=O)C(C=C3)=C2C=C3N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6
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