E3 Ligase Ligand-linker Conjugate 139

Catalog No.: A80168
E3 Ubiquitin Ligase Ligands and Linkers for PROTACs
E3 Ligase Ligand-linker Conjugate 139 is designed to bind to E3 ubiquitin ligases, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates ubiquitination and subsequent degradation of target proteins, making it a valuable tool for cancer research and therapeutic applications. Its unique properties enable efficient disruption of protein homeostasis, offering insights into cellular pathways and potential treatment strategies in oncology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand-linker Conjugate 139 is designed to bind to E3 ubiquitin ligases, serving as a critical component in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates ubiquitination and subsequent degradation of target proteins, making it a valuable tool for cancer research and therapeutic applications. Its unique properties enable efficient disruption of protein homeostasis, offering insights into cellular pathways and potential treatment strategies in oncology.
Product Information
Catalog NumA80168
FormulaC20H25ClF3N3O7
Molecular Weight511.88
CAS Number2375197-04-7
SMILESO=C(C1=CC(NC(CCl)=O)=CC(C(F)(F)F)=C1)NCCC(NCCOCCOCCC(O)=O)=O
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