E3 Ligase Ligand-linker Conjugate 15

Catalog No.: A80143
E3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand-linker Conjugate 15 is a novel conjugate designed for use with E3 ubiquitin ligases. This reagent facilitates the synthesis of complete PROteolysis TArgeting Chimeras (PROTACs), enabling targeted protein degradation. Its application is crucial for researchers investigating protein dynamics and therapeutics aimed at modulating cellular pathways through ubiquitin-mediated degradation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand-linker Conjugate 15 is a novel conjugate designed for use with E3 ubiquitin ligases. This reagent facilitates the synthesis of complete PROteolysis TArgeting Chimeras (PROTACs), enabling targeted protein degradation. Its application is crucial for researchers investigating protein dynamics and therapeutics aimed at modulating cellular pathways through ubiquitin-mediated degradation.
Product Information
Catalog NumA80143
FormulaC24H31N5O4
Molecular Weight453.53
CAS Number2716124-25-1
SMILESO=C1C2=CC=C(N3CCC(CC3)CN4CCC(CC4)N)C=C2C(N1C5C(NC(CC5)=O)=O)=O
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