E3 Ligase Ligand-linker Conjugate 173

Catalog No.: A80255
E3 Ligase Ligand-linker Conjugate

E3 Ligase Ligand-linker Conjugate 173 functions as a specialized ligand-linker conjugate for E3 ligases, facilitating targeted protein degradation. This compound can be utilized to synthesize YN14-H, which demonstrates the ability to induce apoptosis and inhibit cellular migration. Its application in research includes the exploration of antitumor mechanisms in vivo, providing valuable insights into cancer treatment strategies.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description

E3 Ligase Ligand-linker Conjugate 173 functions as a specialized ligand-linker conjugate for E3 ligases, facilitating targeted protein degradation. This compound can be utilized to synthesize YN14-H, which demonstrates the ability to induce apoptosis and inhibit cellular migration. Its application in research includes the exploration of antitumor mechanisms in vivo, providing valuable insights into cancer treatment strategies.

Product Information
Catalog NumA80255
FormulaC29H38ClFN4O5S
Molecular Weight609.15
CAS Number2907682-88-4
SMILESO=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCl
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