E3 Ligase Ligand-linker Conjugate 176

Catalog No.: A80208
E3 Ligase Ligand-linker Conjugate
E3 Ligase Ligand-linker Conjugate 176 is designed to bind specifically to E3 ligases, facilitating targeted protein degradation through the ubiquitin-proteasome system. This conjugate enables the synthesis of BMS-986458, allowing for further exploration of E3 ligase modulation in various biological contexts. It is essential for studies focused on protein homeostasis and the therapeutic potential of targeted protein degradation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand-linker Conjugate 176 is designed to bind specifically to E3 ligases, facilitating targeted protein degradation through the ubiquitin-proteasome system. This conjugate enables the synthesis of BMS-986458, allowing for further exploration of E3 ligase modulation in various biological contexts. It is essential for studies focused on protein homeostasis and the therapeutic potential of targeted protein degradation.
Product Information
Catalog NumA80208
FormulaC19H25N5O2
Molecular Weight355.43
CAS Number3005273-99-1
SMILESC[C@@H]1CNCC[C@H]1NC2=CC=C3C(N(N=C3C4CCC(NC4=O)=O)C)=C2
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