E3 ligase Ligand PG-piperidine-C2-OH

Catalog No.: A80357
E3 Ligase Ligand-Linker Conjugate
E3 ligase Ligand PG-piperidine-C2-OH is a conjugate designed for E3 ligase targeting, featuring a CRBN-based ligand linked to a piperidine moiety. This versatile linker compound serves as a crucial component in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of proteins. Its application in chemical biology research enables the precise modulation of protein levels, contributing to studies in cancer therapeutics and other disease areas.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 ligase Ligand PG-piperidine-C2-OH is a conjugate designed for E3 ligase targeting, featuring a CRBN-based ligand linked to a piperidine moiety. This versatile linker compound serves as a crucial component in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of proteins. Its application in chemical biology research enables the precise modulation of protein levels, contributing to studies in cancer therapeutics and other disease areas.
Product Information
Catalog NumA80357
FormulaC18H24N2O3
Molecular Weight316.40
CAS Number2736510-46-4
SMILESO=C1NC(=O)C(C2=CC=C(C=C2)N3CCC(CCO)CC3)CC1
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