EBI-907 is a potent and orally active inhibitor of the B-RafV600E mutation. It exhibits significant antiproliferative activity in cancer cell lines, demonstrating IC50 values of 13 nM in A375 and 14 nM in Colo-205 cells. In vivo studies show that EBI-907 effectively induces tumor regression in a Colo-205 xenograft model dependent on B-RafV600E. This compound is a valuable tool for research focused on melanoma and cancers associated with B-RafV600E mutations.
EBI-907 is a potent and orally active inhibitor of the B-RafV600E mutation. It exhibits significant antiproliferative activity in cancer cell lines, demonstrating IC50 values of 13 nM in A375 and 14 nM in Colo-205 cells. In vivo studies show that EBI-907 effectively induces tumor regression in a Colo-205 xenograft model dependent on B-RafV600E. This compound is a valuable tool for research focused on melanoma and cancers associated with B-RafV600E mutations.
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