EGFR/AURKB-IN-1 is a dual inhibitor targeting Epidermal Growth Factor Receptor (EGFR) and Aurora Kinase B (AURKB), effectively blocking their phosphorylation with IC50 values of 0.07 µM and 1.1 µM, respectively. This compound binds to the hydrophobic region I and αC-helix out pocket of EGFR, as well as the back pocket of AURKB, thereby inhibiting tumor cell growth, division, and metastasis. EGFR/AURKB-IN-1 is suitable for comprehensive cancer research applications aimed at elucidating mechanisms of tumor progression and therapy resistance.
EGFR/AURKB-IN-1 is a dual inhibitor targeting Epidermal Growth Factor Receptor (EGFR) and Aurora Kinase B (AURKB), effectively blocking their phosphorylation with IC50 values of 0.07 µM and 1.1 µM, respectively. This compound binds to the hydrophobic region I and αC-helix out pocket of EGFR, as well as the back pocket of AURKB, thereby inhibiting tumor cell growth, division, and metastasis. EGFR/AURKB-IN-1 is suitable for comprehensive cancer research applications aimed at elucidating mechanisms of tumor progression and therapy resistance.
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