EGFR/HER2-IN-5 is an orally active irreversible dual inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). It exhibits a potent inhibitory effect on EGFR with an IC50 value of 1.01 nM and effectively inhibits EGFR kinase activity associated with L858R and T790M mutations. This compound demonstrates significant antitumor efficacy in vivo, making it a valuable tool for lung cancer research and the development of targeted therapies in oncology.
EGFR/HER2-IN-5 is an orally active irreversible dual inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). It exhibits a potent inhibitory effect on EGFR with an IC50 value of 1.01 nM and effectively inhibits EGFR kinase activity associated with L858R and T790M mutations. This compound demonstrates significant antitumor efficacy in vivo, making it a valuable tool for lung cancer research and the development of targeted therapies in oncology.
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