EGFR-IN-1 hydrochloride is an orally active and irreversible inhibitor targeting the mutant EGFR L858R/T790M. This compound exhibits potent inhibition of Gefitinib-resistant EGFR variants with a selectivity ratio of 100-fold over wild-type EGFR. Notably, EGFR-IN-1 hydrochloride demonstrates significant antiproliferative activity against H1975 and HCC827 cell lines, making it a valuable tool for antitumor research applications in cancer studies related to resistant EGFR mutations.
EGFR-IN-1 hydrochloride is an orally active and irreversible inhibitor targeting the mutant EGFR L858R/T790M. This compound exhibits potent inhibition of Gefitinib-resistant EGFR variants with a selectivity ratio of 100-fold over wild-type EGFR. Notably, EGFR-IN-1 hydrochloride demonstrates significant antiproliferative activity against H1975 and HCC827 cell lines, making it a valuable tool for antitumor research applications in cancer studies related to resistant EGFR mutations.
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