EGFR-IN-1 TFA is an irreversible inhibitor targeting the EGFR L858R/T790M mutant, specifically designed to overcome resistance to Gefitinib. It demonstrates exceptional potency, exhibiting a 100-fold selectivity over wild-type EGFR. This compound shows robust antiproliferative effects against H1975 and HCC827 cell lines, highlighting its potential for antitumor applications in the treatment of lung cancer driven by these mutations.
EGFR-IN-1 TFA is an irreversible inhibitor targeting the EGFR L858R/T790M mutant, specifically designed to overcome resistance to Gefitinib. It demonstrates exceptional potency, exhibiting a 100-fold selectivity over wild-type EGFR. This compound shows robust antiproliferative effects against H1975 and HCC827 cell lines, highlighting its potential for antitumor applications in the treatment of lung cancer driven by these mutations.
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