EGFR-IN-1 is an orally active, irreversible inhibitor selectively targeting the EGFR L858R/T790M mutants. This compound demonstrates potent inhibition of Gefitinib-resistant EGFR variants with over 100-fold selectivity compared to wild-type EGFR. EGFR-IN-1 exhibits significant antiproliferative effects in both H1975 and mutated HCC827 cancer cell lines, indicating its potential utility in anticancer research and therapeutic applications.
EGFR-IN-1 is an orally active, irreversible inhibitor selectively targeting the EGFR L858R/T790M mutants. This compound demonstrates potent inhibition of Gefitinib-resistant EGFR variants with over 100-fold selectivity compared to wild-type EGFR. EGFR-IN-1 exhibits significant antiproliferative effects in both H1975 and mutated HCC827 cancer cell lines, indicating its potential utility in anticancer research and therapeutic applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
