EGFR-IN-197 is a potent inhibitor of the Epidermal Growth Factor Receptor (EGFR), displaying IC50 values of 19.5 nM and 12.0 nM against the EGFRL858R/T790M and EGFRL858R/T790M/C797S mutations, respectively. This compound effectively arrests the cell cycle in the G2/M phase, inhibiting proliferation, colony formation, and migration of NCI-H1975 cells. Additionally, EGFR-IN-197 disrupts anti-apoptotic signaling pathways, induces DNA damage, and activates pro-apoptotic pathways, thereby triggering apoptosis. Its properties make it a valuable reagent for research focused on non-small cell lung cancer (NSCLC).
EGFR-IN-197 is a potent inhibitor of the Epidermal Growth Factor Receptor (EGFR), displaying IC50 values of 19.5 nM and 12.0 nM against the EGFRL858R/T790M and EGFRL858R/T790M/C797S mutations, respectively. This compound effectively arrests the cell cycle in the G2/M phase, inhibiting proliferation, colony formation, and migration of NCI-H1975 cells. Additionally, EGFR-IN-197 disrupts anti-apoptotic signaling pathways, induces DNA damage, and activates pro-apoptotic pathways, thereby triggering apoptosis. Its properties make it a valuable reagent for research focused on non-small cell lung cancer (NSCLC).
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
