EGFR-IN-25 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 9 nM in BaF3 cells harboring the EGFR DEL19/T790M/C797S mutation and 60 nM in A431 cells expressing wild-type EGFR. This compound exhibits significant biological activity that supports its application in cancer research, particularly in studies targeting EGFR-driven tumors. EGFR-IN-25 can be utilized to investigate the effects of EGFR inhibition on cell proliferation and survival in relevant preclinical models.
EGFR-IN-25 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 9 nM in BaF3 cells harboring the EGFR DEL19/T790M/C797S mutation and 60 nM in A431 cells expressing wild-type EGFR. This compound exhibits significant biological activity that supports its application in cancer research, particularly in studies targeting EGFR-driven tumors. EGFR-IN-25 can be utilized to investigate the effects of EGFR inhibition on cell proliferation and survival in relevant preclinical models.
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