EGFR-IN-43 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with sub-nanomolar activity. This compound uniquely fuses tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bond, allowing it to exhibit both estrogen receptor antagonist properties and effective EGFR inhibition. EGFR-IN-43 demonstrates enhanced anti-cancer effects, making it a valuable tool for studies on targeted therapies in cancer research.
EGFR-IN-43 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with sub-nanomolar activity. This compound uniquely fuses tamoxifen or endoxifen with the EGFR inhibitor gefitinib through a covalent bond, allowing it to exhibit both estrogen receptor antagonist properties and effective EGFR inhibition. EGFR-IN-43 demonstrates enhanced anti-cancer effects, making it a valuable tool for studies on targeted therapies in cancer research.
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