EGFR-IN-49 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 65.0 nM for EGFRT790M and 13.6 nM for EGFRT790M/L858R variants. This compound effectively induces late apoptosis in a dose-dependent manner, making it a valuable tool for studying cancer cell signaling and apoptosis mechanisms. Its potency and selectivity position EGFR-IN-49 as a promising reagent for research applications focused on targeting EGFR-related pathways in cancer therapeutics.
EGFR-IN-49 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 65.0 nM for EGFRT790M and 13.6 nM for EGFRT790M/L858R variants. This compound effectively induces late apoptosis in a dose-dependent manner, making it a valuable tool for studying cancer cell signaling and apoptosis mechanisms. Its potency and selectivity position EGFR-IN-49 as a promising reagent for research applications focused on targeting EGFR-related pathways in cancer therapeutics.
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